Determination of avermectins in commercial formulations using microemulsion electrokinetic chromatography

被引：40

作者：

Seelanan, Parinya

Srisa-art, Monpichar

Petsom, Amorn

Nhujak, Thumnoon ^{[1
]}

机构：

[1] Chulalongkorn Univ, Fac Sci, Dept Chem, Chromatog & Separat Grp, Bangkok 10330, Thailand

[2] Chulalongkorn Univ, Fac Sci, Dept Chem, Res Ctr Bioorgan Chem, Bangkok 10330, Thailand

来源：

ANALYTICA CHIMICA ACTA | 2006年 / 570卷 / 01期

关键词：

avermectins; abamectin; doramectin; ivermectin; microemulsion electrokinetic chromatography; capillary electrophoresis;

D O I：

10.1016/j.aca.2006.03.110

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Microemulsion electrokinetic chromatography (MEEKC) was developed for quantitative analysis of avermectins, such as abamectin, doramectin and ivermectin, in commercial formulations, using the microemulsion buffer containing a 50 mM phosphate buffer at pH 2.5, 1.1% (v/v) n-octane as oil droplets, 180 mM sodium dodecylsulphate as surfactant, 890 mM 1-butanol as co-surfactant and 30% (v/v) ethanol as organic co-solvent. High accuracy and precision of the method were obtained. The contents of avermectins in commercial formulations determined by MEEKC were found to be insignificantly different with those determined by high performance liquid chromatography (HPLC). Therefore, MEEKC can be used an alternative method to HPLC for quantitative determination of avermectins. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：8 / 14

页数：7

共 28 条

[1] The effect of operating variables in microemulsion electrokinetic capillary chromatography [J].