Changes in antioxidant status of lung tissue in experimental diabetes in rabbits

被引：47

作者：

Gumieniczek, A

Hopkala, H

Wójtowicz, Z

Wysocka, M

机构：

[1] Med Univ Lublin, Dept Med Chem, PL-20093 Lublin, Poland

[2] Med Univ Lublin, Dept Human Physiol Anat, PL-20074 Lublin, Poland

来源：

CLINICAL BIOCHEMISTRY | 2002年 / 35卷 / 02期

关键词：

alloxan-diabetes; lung; antioxidative system;

D O I：

10.1016/S0009-9120(02)00282-5

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 [基础医学];

摘要：

Objectives: Hyperglycaemia can result in oxidative stress which may affected as cellular tissue damage. Design and methods: After 3, 6, 12 and 24 weeks of hyperglycaemia oxidative stress related parameters were measured in lung tissue of diabetic and control rabbits. Results: Decreased activities of antioxidative compounds and intensification of lipid peroxidation process were found in diabetic lung. Conclusions: The data obtained suggest that hyperglycaemia induces oxidative stress in lung tissue which may play an important role in pathogenesis of diabetic complications. (C) 2002 The Canadian Society of Clinical Chemists. All rights reserved.

引用

页码：147 / 149

页数：3

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