Selective ion extraction: a separation method for microfluidic devices

被引：25

作者：

Kerby, MB ^{[1
]}

Spaid, M ^{[1
]}

Wu, S ^{[1
]}

Parce, JW ^{[1
]}

Chien, RL ^{[1
]}

机构：

[1] Caliper Technol Corp, Mt View, CA 94043 USA

来源：

ANALYTICAL CHEMISTRY | 2002年 / 74卷 / 20期

关键词：

D O I：

10.1021/ac0258103

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A separation concept, selective ion extraction (SIE), is proposed on the basis of the combination of hydrodynamic and electrokinetic flow controls in microfluidic devices. Using a control system with multiple pressure and voltage sources, the hydrodynamic flow and electric field in any section of the microfluidic network can be set to desired values. Mixtures of compounds sent into a T-junction on a chip can be completely separated into different channels on the basis of their electrophoretic mobilities. A simple velocity balance model proved useful for predicting the voltage and pressure settings needed for separation. SIE provides a highly efficient separation with minimal additional dispersion. It is an ideal technique for high-throughput screening systems and demonstrates the power of lab-on-a-chip systems.

引用

页码：5175 / 5183

页数：9

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