Electrokinetically controlled microfluidic analysis systems

被引：168

作者：

Bousse, L ^{[1
]}

Cohen, C ^{[1
]}

Nikiforov, T ^{[1
]}

Chow, A ^{[1
]}

Kopf-Sill, AR ^{[1
]}

Dubrow, R ^{[1
]}

Parce, JW ^{[1
]}

机构：

[1] Caliper Technol Corp, Mountain View, CA 94043 USA

来源：

ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE | 2000年 / 29卷

关键词：

bioassays; integrated systems; microfabrication; lab-on-a-chip;

D O I：

10.1146/annurev.biophys.29.1.155

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Electrokinetic forces are emerging as a powerful means to drive microfluidic systems with how channel cross-sectional dimensions in the tens of micrometers and flow rates in the nanoliter per second range. These systems provide many advantages such as improved analysis speed, improved reproducibility, greatly reduced reagent consumption, and the ability to perform multiple operations in an integrated fashion. Planar microfabrication methods are used to make these analysis chips in materials such as glass or polymers. Many applications of this technology have been demonstrated, such as DNA separations, enzyme assays, immunoassays, and PCR amplification integrated with microfluidic assays. Further development of this technology is expected to yield higher levers of functionality of sample throughput on a single microfluidic analysis chip.

引用

页码：155 / 181

页数：27

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