Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation

被引：154

作者：

Keeney, S.

Neale, M. J.

机构：

[1] Mem Sloan Kettering Canc Ctr, Program Mol Biol, New York, NY 10021 USA

[2] Gerstner Sloan Kettering Grad Sch Biomed Sci, New York, NY 10021 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2006年 / 34卷

关键词：

cyclin-dependent kinase; DNA double-strand break; homologous recombination; meiosis; Mre11-Rad50-Xrs2; complex; Spo11;

D O I：

10.1042/BST0340523

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

organisms. Meiotic recombination is initiated by the formation of DSBs (DNA double-strand breaks) made by the Spo11 protein. We review here recent findings pertaining to protein-protein interactions important for DSB formation, the mechanism of an early step in the processing of Spo11-generated DSBs, and regulation of DSB formation by protein kinases.

引用

收藏

页码：523 / 525

页数：3

相关论文

共 39 条

[1] The 3′ to 5′ degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3′ to 5′ exonucleases of the exosome complex [J].

Anderson, JSJ ;

Parker, R .

EMBO JOURNAL, 1998, 17 (05) :1497-1506

[2] Ski7p G protein interacts with the exosome and the Ski complex for 3′-to-5′ mRNA decay in yeast [J].

Araki, Y ;

Takahashi, S ;

Kobayashi, T ;

Kajiho, H ;

Hoshino, S ;

Katada, T .

EMBO JOURNAL, 2001, 20 (17) :4684-4693

[3] Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism [J].

Arora, C ;

Kee, K ;

Maleki, S ;

Keeney, S .

MOLECULAR CELL, 2004, 13 (04) :549-559

[4] An atypical topoisomerase II from archaea with implications for meiotic recombination [J].

Bergerat, A ;

deMassy, B ;

Gadelle, D ;

Varoutas, PC ;

Nicolas, A ;

Forterre, P .

NATURE, 1997, 386 (6623) :414-417

[5] C-elegans mre-11 is required for meiotic recombination and DNA repair but is dispensable for the meiotic G2 DNA damage checkpoint [J].

Chin, GM ;

Villeneuve, AM .

GENES & DEVELOPMENT, 2001, 15 (05) :522-534

[6] Repair of DNA covalently linked to protein [J].

Connelly, JC ;

Leach, DRF .

MOLECULAR CELL, 2004, 13 (03) :307-316

[7] Tethering on the brink: the evolutionarily conserved Mre11-Rad50 complex [J].

Connelly, JC ;

Leach, DRF .

TRENDS IN BIOCHEMICAL SCIENCES, 2002, 27 (08) :410-418

[8]

Evans DH, 1997, GENETICS, V146, P1253

[9] Control of meiotic recombination in Schizosaccharomyces pombe [J].

Fox, ME ;

Smith, GR .

PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 61, 1998, 61 :345-378

[10]

Gardiner JM, 1997, GENETICS, V146, P1265

← 1 2 3 4 →