Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation

被引：154

作者：

Keeney, S.

Neale, M. J.

机构：

[1] Mem Sloan Kettering Canc Ctr, Program Mol Biol, New York, NY 10021 USA

[2] Gerstner Sloan Kettering Grad Sch Biomed Sci, New York, NY 10021 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2006年 / 34卷

关键词：

cyclin-dependent kinase; DNA double-strand break; homologous recombination; meiosis; Mre11-Rad50-Xrs2; complex; Spo11;

D O I：

10.1042/BST0340523

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

organisms. Meiotic recombination is initiated by the formation of DSBs (DNA double-strand breaks) made by the Spo11 protein. We review here recent findings pertaining to protein-protein interactions important for DSB formation, the mechanism of an early step in the processing of Spo11-generated DSBs, and regulation of DSB formation by protein kinases.

引用

页码：523 / 525

页数：3

共 39 条

[21] The mouse meiotic mutation mei1 disrupts chromosome synapsis with sexually dimorphic consequences for meiotic progression [J].