A transcriptomic atlas of mammalian olfactory mucosae reveals an evolutionary influence on food odor detection in humans

被引：54

作者：

Saraiva, Luis R. ^{[1
,2
,3
,4
]}

Riveros-McKay, Fernando ^{[2
]}

Mezzavilla, Massimo ^{[1
]}

Abou-Moussa, Eman H. ^{[1
]}

Arayata, Charles J. ^{[4
]}

Makhlouf, Melanie ^{[1
]}

Trimmer, Casey ^{[4
]}

Ibarra-Soria, Ximena ^{[2
]}

Khan, Mona ^{[5
]}

Van Gerven, Laura ^{[6
]}

Jorissen, Mark ^{[6
]}

Gibbs, Matthew ^{[7
]}

O'Flynn, Ciaran ^{[7
]}

McGrane, Scott ^{[7
]}

Mombaerts, Peter ^{[5
]}

Marioni, John C. ^{[2
,3
,8
]}

Mainland, Joel D. ^{[4
,9
]}

Logan, Darren W. ^{[2
,4
,7
]}

机构：

[1] Sidra Med, POB 26999, Doha, Qatar

[2] Wellcome Sanger Inst, Wellcome Genome Campus, Cambridge CB10 1SD, England

[3] European Bioinformat Inst EMBL EBI, European Mol Biol Lab, Wellcome Genome Campus, Cambridge CB10 1SD, England

[4] Monell Chem Senses Ctr, 3500 Market St, Philadelphia, PA 19104 USA

[5] Max Planck Res Unit Neurogenet, Max von Laue Str 4, D-60438 Frankfurt, Germany

[6] UZ Leuven, Dept ENT HNS, Herestr 49, B-3000 Leuven, Belgium

[7] Waltham Ctr Pet Nutr, Melton Mowbray LE14 4RT, Leics, England

[8] Univ Cambridge, CRUK Cambridge Inst, Cambridge CB2 0RE, England

[9] Univ Penn, Dept Neurosci, Philadelphia, PA 19104 USA

来源：

SCIENCE ADVANCES | 2019年 / 5卷 / 07期

基金：

英国惠康基金;

关键词：

GENETIC-VARIATION; RECEPTOR; REPERTOIRE; VALIDATION; EXPERIENCE; NEURONS; LIGAND; SMELL;

D O I：

10.1126/sciadv.aax0396

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mammalian olfactory system displays species-specific adaptations to different ecological niches. To investigate the evolutionary dynamics of olfactory sensory neuron (OSN) subtypes across mammalian evolution, we applied RNA sequencing of whole olfactory mucosa samples from mouse, rat, dog, marmoset, macaque, and human. We find that OSN subtypes, representative of all known mouse chemosensory receptor gene families, are present in all analyzed species. Further, we show that OSN subtypes expressing canonical olfactory receptors are distributed across a large dynamic range and that homologous subtypes can be either highly abundant across all species or species/order specific. Highly abundant mouse and human OSN subtypes detect odorants with similar sensory profiles and sense ecologically relevant odorants, such as mouse semiochemicals or human key food odorants. Together, our results allow for a better understanding of the evolution of mammalian olfaction in mammals and provide insights into the possible functions of highly abundant OSN subtypes.

引用

页数：11

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