Substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles as Src kinase inhibitors

被引：33

作者：

Berger, D ^{[1
]}

Dutia, M

Powell, D

Wissner, A

DeMorin, F

Raifeld, Y

Weber, J

Boschelli, F

机构：

[1] Wyeth Ayerst Res, Chem Sci, Pearl River, NY 10965 USA

[2] Wyeth Ayerst Res, Discovery Oncol, Pearl River, NY 10965 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(02)00577-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles has been prepared as Src kinase inhibitors. Optimal activity is observed with compounds that have basic amines attached via the para position of the 7-phenyl ring, and a hydrogen atom at the C-6 position. The best compounds are low nanomolar inhibitors of Src kinase, and have potent activity against Src-transformed fibroblast cells. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：2989 / 2992

页数：4

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