The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update

被引:2537
作者
Afgan, Enis [1 ]
Baker, Dannon [1 ]
Batut, Berenice [2 ]
van den Beek, Marius [3 ]
Bouvier, Dave [4 ]
Cech, Martin [4 ]
Chilton, John [4 ]
Clements, Dave [1 ]
Coraor, Nate [4 ]
Gruening, Bjoern A. [2 ,5 ]
Guerler, Aysam [1 ]
Hillman-Jackson, Jennifer [4 ]
Hiltemann, Saskia [6 ]
Jalili, Vahid [7 ]
Rasche, Helena [2 ]
Soranzo, Nicola [8 ]
Goecks, Jeremy [7 ]
Taylor, James [1 ]
Nekrutenko, Anton [4 ]
Blankenberg, Daniel [9 ]
机构
[1] Johns Hopkins Univ, Dept Biol, Baltimore, MD 21218 USA
[2] Albert Ludwigs Univ, Dept Comp Sci, Freiburg, Freiburg, Germany
[3] PSL Res Univ, Inst Curie, Paris, France
[4] Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA
[5] Univ Freiburg, Ctr Biol Syst Anal ZBSA, Freiburg, Germany
[6] Erasmus MC, Dept Pathol, Rotterdam, Netherlands
[7] Oregon Hlth & Sci Univ, Dept Biomed Engn, Portland, OR 97201 USA
[8] Earlham Inst, Norwich Res Pk, Norwich, Norfolk, England
[9] Cleveland Clin, Genom Med Inst, Lerner Res Inst, Cleveland, OH 44106 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
WEB; BIOINFORMATICS; FRAMEWORK; TOOLS; RNA;
D O I
10.1093/nar/gky379
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Galaxy (homepage: https://galaxyproject.org, main public server: https://usegalaxy.org) is a web-based scientific analysis platform used by tens of thousands of scientists across the world to analyze large biomedical datasets such as those found in genomics, proteomics, metabolomics and imaging. Started in 2005, Galaxy continues to focus on three key challenges of data-driven biomedical science: making analyses accessible to all researchers, ensuring analyses are completely reproducible, and making it simple to communicate analyses so that they can be reused and extended. During the last two years, the Galaxy team and the open-source community around Galaxy have made substantial improvements to Galaxy's core framework, user interface, tools, and training materials. Framework and user interface improvements now enable Galaxy to be used for analyzing tens of thousands of datasets, and >5500 tools are now available from the Galaxy ToolShed. The Galaxy community has led an effort to create numerous high-quality tutorials focused on common types of genomic analyses. The Galaxy developer and user communities continue to grow and be integral to Galaxy's development. The number of Galaxy public servers, developers contributing to the Galaxy framework and its tools, and users of the main Galaxy server have all increased substantially.
引用
收藏
页码:W537 / W544
页数:8
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