Triterpenoid Saponins from Lysimachia davurica

被引：15

作者：

Liang, Bo

Tian, Jing-Kui ^{[1
]}

Xu, Li-Zhen

Yang, Shi-Lin

机构：

[1] Zhejiang Univ, Dept Chinese Med Sci & Engn, Hangzhou 310028, Peoples R China

[2] Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100094, Peoples R China

[3] Peking Union Med Coll, Beijing 100094, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2006年 / 54卷 / 10期

关键词：

Lysimachia davurica; triterpene; saponin; 3-O-beta-D-glucopyranosyl-(1 -> 2)-[beta-D-glucopyranosyl-(1 -> 4)]-alpha-L-arabinopyranosyl-13,28-epoxy-3 beta-hydroxy-16-oleanaone; 3-O-beta-D-glucopyranosyloxyuronic acid-(1 -> 2)-beta-D-xylopyranosyl-cyclamiretin A; 3-O-beta-D-glucopyranosyl-(1 -> 2)-alpha-L-arabinopyranosyl-cyclamiretin A;

D O I：

10.1248/cpb.54.1380

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new saponins were isolated from the whole plants of Lysimachia davurica. On the basis of 1D and 2D NMR (H-1-(HCOSY)-H-1, HMBC, HMQC, and TOCSY) techniques, MS, and hydrolysis, their structures were found to be 3-O-beta-D-glucopyranosyl-(1 -> 2)-[beta-D-glucopyranosyl-(1 -> 4)]-alpha-L-arabinopyranosyl-13,28-epoxy-3 beta-hydroxy-16-oleanaone (1), 3-O-beta-D-glucopyranosyloxyuronic acid-(1 -> 2)-beta-D-xylopyranosyl-cyclamiretin A (2), and 3-O-beta-D-glucopyranosyl-(1 -> 2)-alpha-L-arabinopyranosyl-cyclamiretin A (3), respectively. Compounds 2 and 3 showed significant cytotoxicities against human A-2780 cells.

引用

页码：1380 / 1383

页数：4

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