Deletion of nef slows but does not prevent CD4-positive T-cell depletion in human immunodeficiency virus type 1-infected human-PBL-SCID mice

被引：37

作者：

Gulizia, RJ

Collman, RG

Levy, JA

Trono, D

Mosier, DE

机构：

[1] Scripps Res Inst, DEPT IMMUNOL, IMM7, LA JOLLA, CA 92037 USA

[2] SALK INST BIOL STUDIES, LA JOLLA, CA 92037 USA

[3] UNIV PENN, DEPT MED, PHILADELPHIA, PA 19104 USA

[4] UNIV CALIF SAN FRANCISCO, DEPT MED, CANC RES INST, SAN FRANCISCO, CA 94143 USA

来源：

JOURNAL OF VIROLOGY | 1997年 / 71卷 / 05期

关键词：

D O I：

10.1128/JVI.71.5.4161-4164.1997

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The pathogenicity of four human immunodeficiency virus type 1 (HIV-1) isolates with nef deleted for SCID mice repopulated with human peripheral blood leukocytes (hu-PBL-SCID mice) was studied. Deletion of nef led to a substantial reduction in CD4-positive T-cell depletion and delayed kinetics of plasma viremia in infected hu-PBL-SCID mice. Deletion of the nef gene impacts both the efficiency of primary infection and the cytopathicity of virus for infected CD4-positive T cells in this animal model of HIV-1 infection.

引用

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页码：4161 / 4164

页数：4

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