Deletion of nef slows but does not prevent CD4-positive T-cell depletion in human immunodeficiency virus type 1-infected human-PBL-SCID mice

被引：37

作者：

Gulizia, RJ

Collman, RG

Levy, JA

Trono, D

Mosier, DE

机构：

[1] Scripps Res Inst, DEPT IMMUNOL, IMM7, LA JOLLA, CA 92037 USA

[2] SALK INST BIOL STUDIES, LA JOLLA, CA 92037 USA

[3] UNIV PENN, DEPT MED, PHILADELPHIA, PA 19104 USA

[4] UNIV CALIF SAN FRANCISCO, DEPT MED, CANC RES INST, SAN FRANCISCO, CA 94143 USA

来源：

JOURNAL OF VIROLOGY | 1997年 / 71卷 / 05期

关键词：

D O I：

10.1128/JVI.71.5.4161-4164.1997

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The pathogenicity of four human immunodeficiency virus type 1 (HIV-1) isolates with nef deleted for SCID mice repopulated with human peripheral blood leukocytes (hu-PBL-SCID mice) was studied. Deletion of nef led to a substantial reduction in CD4-positive T-cell depletion and delayed kinetics of plasma viremia in infected hu-PBL-SCID mice. Deletion of the nef gene impacts both the efficiency of primary infection and the cytopathicity of virus for infected CD4-positive T cells in this animal model of HIV-1 infection.

引用

收藏

页码：4161 / 4164

页数：4

相关论文

共 43 条

[21] REQUIREMENT OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 NEF FOR IN-VIVO REPLICATION AND PATHOGENICITY [J].

JAMIESON, BD ;

ALDROVANDI, GM ;

PLANELLES, V ;

JOWETT, JBM ;

GAO, LY ;

BLOCH, LM ;

CHEN, ISY ;

ZACK, JA .

JOURNAL OF VIROLOGY, 1994, 68 (06) :3478-3485

[22] IMPORTANCE OF THE NEF GENE FOR MAINTENANCE OF HIGH VIRUS LOADS AND FOR DEVELOPMENT OF AIDS [J].

KESTLER, HW ;

RINGLER, DJ ;

MORI, K ;

PANICALI, DL ;

SEHGAL, PK ;

DANIEL, MD ;

DESROSIERS, RC .

CELL, 1991, 65 (04) :651-662

[23] BRIEF REPORT - ABSENCE OF INTACT NEF SEQUENCES IN A LONG-TERM SURVIVOR WITH NONPROGRESSIVE HIV-1 INFECTION [J].

KIRCHHOFF, F ;

GREENOUGH, TC ;

BRETTLER, DB ;

SULLIVAN, JL ;

DESROSIERS, RC .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (04) :228-232

[24] ISOLATION OF LYMPHOCYTOPATHIC RETROVIRUSES FROM SAN-FRANCISCO PATIENTS WITH AIDS [J].

LEVY, JA ;

HOFFMAN, AD ;

KRAMER, SM ;

LANDIS, JA ;

SHIMABUKURO, JM .

SCIENCE, 1984, 225 (4664) :840-842

[25] MUTATIONAL ANALYSIS OF THE HUMAN-IMMUNODEFICIENCY-VIRUS - THE ORF-B REGION DOWN-REGULATES VIRUS-REPLICATION [J].

LUCIW, PA ;

CHENGMAYER, C ;

LEVY, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (05) :1434-1438

[26] High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection [J].

Mariani, R ;

Kirchhoff, F ;

Greenough, TC ;

Sullivan, JL ;

Desrosiers, RC ;

Skowronski, J .

JOURNAL OF VIROLOGY, 1996, 70 (11) :7752-7764

[27] FUNCTIONAL-CHARACTERIZATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 NEF GENES IN PATIENTS WITH DIVERGENT RATES OF DISEASE PROGRESSION [J].

MICHAEL, NL ;

CHANG, G ;

DARCY, LA ;

TSENG, CJ ;

BIRX, DL ;

SHEPPARD, HW .

JOURNAL OF VIROLOGY, 1995, 69 (11) :6758-6769

[28] DEFECTIVE ACCESSORY GENES IN A HUMAN-IMMUNODEFICIENCY-VIRUS TYPE 1-INFECTED LONG-TERM SURVIVOR LACKING RECOVERABLE VIRUS [J].

MICHAEL, NL ;

CHANG, G ;

DARCY, LA ;

EHRENBERG, PK ;

MARIANI, R ;

BUSCH, MP ;

BIRX, DL ;

SCHWARTZ, DH .

JOURNAL OF VIROLOGY, 1995, 69 (07) :4228-4236

[29] THE HUMAN IMMUNODEFICIENCY VIRUS-1 NEF GENE-PRODUCT - A POSITIVE FACTOR FOR VIRAL-INFECTION AND REPLICATION IN PRIMARY LYMPHOCYTES AND MACROPHAGES [J].

MILLER, MD ;

WARMERDAM, MT ;

GASTON, I ;

GREENE, WC ;

FEINBERG, MB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (01) :101-113

[30] RAPID LOSS OF CD4+ T-CELLS IN HUMAN-PBL-SCID MICE BY NONCYTOPATHIC HIV ISOLATES [J].

MOSIER, DE ;

GULIZIA, RJ ;

MACISAAC, PD ;

TORBETT, BE ;

LEVY, JA .

SCIENCE, 1993, 260 (5108) :689-692

← 1 2 3 4 5 →