Mass-selective ion accumulation and fragmentation in a linear octopole ion trap external to a Fourier transform ion cyclotron resonance mass spectrometer

被引：39

作者：

Wang, Y

Shi, SDH

Hendrickson, CL

Marshall, AG ^{[1
]}

机构：

[1] Florida State Univ, Natl High Field Lab, Ctr Interdisciplinary Magnet Resonance, Tallahassee, FL 32310 USA

[2] Florida State Univ, Dept Chem, Tallahassee, FL 32310 USA

来源：

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY | 2000年 / 198卷 / 1-2期

基金：

美国国家科学基金会;

关键词：

mass filter; Fourier transform ion cyclotron resonance (FTICR); Fourier transform mass spectrometry (FTMS); protein; collision-activated dissociation (CAD); collision-induced dissociation (CID); fragmentation;

D O I：

10.1016/S1387-3806(00)00177-9

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

Electrosprayed protein ions are accumulated and mass selected in an external linear octopole trap before injection into a Fourier transform ion cyclotron resonance (FTICR) mass spectrometer. Mass selection is performed by application of superimposed rf and de octopole electric potentials during ion accumulation. Ion trajectory stability and mass selection in the octopole field are explained qualitatively by analogy to a quadrupole mass filter. Accumulation of ions from a selected m/z range is demonstrated experimentally for 7 and 9.4 T electrospray ionization (ESI) FTICR mass spectrometers. Ion fragmentation in the octopole may occur under certain operating conditions. (C) 2000 Elsevier Science B.V.

引用

页码：113 / 120

页数：8

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