Cytotoxic clerodane diterpenoids from the leaves of Premna tomentosa

被引：25

作者：

Chin, Young-Won

Jones, William P.

Mi, Qiuwen

Rachman, Ismail

Riswan, Soedarsono

Kardono, Leonardus B. S.

Chai, Hee-Byung

Farnsworth, Norman R.

Cordell, Geoffrey A.

Swanson, Steven M.

Cassady, John M.

Kinghorn, A. Douglas ^{[1
]}

机构：

[1] Ohio State Univ, Coll Pharm, Div Med Chem & Pharmacognosy, Columbus, OH 43210 USA

[2] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA

[3] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA

[4] Indonesian Inst Sci, Res Ctr Biol, Bogor 16122, Indonesia

[5] Indonesian Inst Sci, Res Ctr Chem, Tangerang 15310, Indonesia

[6] Herbarium Bogoriense, Bogor, Indonesia

来源：

PHYTOCHEMISTRY | 2006年 / 67卷 / 12期

关键词：

Premna tomentosa; verbenaceae; clerodane diterpenoids; premnones A-C; flavonoids; triterpenoids; cytotoxicity; hollow fiber assay;

D O I：

10.1016/j.phytochem.2006.04.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three clerodane diterpenoids, premnones A-C (1-3), were isolated from a chloroform-soluble fraction of Premna tomentosa along with four known flavonoids and three known triterpenoids. Among these isolates, premnones A-C exhibited cytotoxic activity when evaluated against a small panel of tumor cell lines. However, premnone A was found to be inactive when evaluated in a follow-up in vivo hollow fiber assay at the highest dose tested (50 mg/kg), using LNCaP, Lu1, and MCF-7 cells. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1243 / 1248

页数：6

共 23 条

[1]

Balakrishna K, 2003, J INDIAN CHEM SOC, V80, P792

[2] NATURALLY OCCURRING TERPENE DERIVATIVES .201. NEW DITERPENIC ACID FROM CENTIPEDA-ORBICULARIS [J].