Multiplicity of Ca2+ messengers and Ca2+ stores:: A perspective from cyclic ADP-ribose and NAADP

被引:109
作者
Lee, HC [1 ]
机构
[1] Univ Minnesota, Dept Pharmacol, Minneapolis, MN 55455 USA
关键词
cyclic ADP-Ribose (cADPR); NAADP; ADP-ribosyl cyclase; CD38; mobilization of Ca2+ stores; Ca2+ signaling;
D O I
10.2174/1566524043360753
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
It is generally believed that multiple Ca2+ stores are present in cells, a notion that has now been made substantive by the discovery of multiple Ca2+ mobilizing messengers. Cyclic ADP-ribose (cADPR) and nicotinic acid dinucleotide phosphate (NAADP) are two such messengers that are derived from NAD and NADP, respectively. A wide variety of cells, from plants to mammals, including human, have been shown to be responsive to these two novel Ca2+ messengers. Not only are their structures and mechanisms of action different, their targeted Ca2+ stores are also distinct and separable. This article explores the implications of the multiplicity of Ca2+ stores in cellular signaling. Special emphasis will be put on the recent progress in the understanding of the physiological functions of NAADP.
引用
收藏
页码:227 / 237
页数:11
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