Phase-resolved optical coherence tomography and optical Doppler tomography for imaging blood flow in human skin with fast scanning speed and high velocity sensitivity

被引:564
作者
Zhao, YH [1 ]
Chen, ZP [1 ]
Saxer, C [1 ]
Xiang, SH [1 ]
de Boer, JF [1 ]
Nelson, JS [1 ]
机构
[1] Univ Calif Irvine, Beckman Laser Inst & Med Clin, Irvine, CA 92612 USA
关键词
D O I
10.1364/OL.25.000114
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
We have developed a novel phase-resolved optical coherence tomography (OCT) and optical Doppler tomography (ODT) system that uses phase information derived from a Hilbert transformation to image blood flow in human skin with fast scanning speed and high velocity sensitivity. Using the phase change between sequential scans to construct flow-velocity imaging, this technique decouples spatial resolution and velocity sensitivity in flow images and increases imaging speed by more than 2 orders of magnitude without compromising spatial resolution or velocity sensitivity. The minimum flow velocity that can be detected with an axial-line scanning speed of 400 Hz and an average phase change over eight sequential scans is as low as 10 mu m/s, while a spatial resolution of 10 mu m is maintained. Using this technique, we present what are to our knowledge the first phase-resolved OCT/ODT images of blood flow in human shin. (C) 2000 Optical Society of America OCIS codes: 110.4500, 170.3880, 100.5070.
引用
收藏
页码:114 / 116
页数:3
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