Phase-resolved optical coherence tomography and optical Doppler tomography for imaging blood flow in human skin with fast scanning speed and high velocity sensitivity

被引：564

作者：

Zhao, YH ^{[1
]}

Chen, ZP ^{[1
]}

Saxer, C ^{[1
]}

Xiang, SH ^{[1
]}

de Boer, JF ^{[1
]}

Nelson, JS ^{[1
]}

机构：

[1] Univ Calif Irvine, Beckman Laser Inst & Med Clin, Irvine, CA 92612 USA

来源：

OPTICS LETTERS | 2000年 / 25卷 / 02期

关键词：

D O I：

10.1364/OL.25.000114

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We have developed a novel phase-resolved optical coherence tomography (OCT) and optical Doppler tomography (ODT) system that uses phase information derived from a Hilbert transformation to image blood flow in human skin with fast scanning speed and high velocity sensitivity. Using the phase change between sequential scans to construct flow-velocity imaging, this technique decouples spatial resolution and velocity sensitivity in flow images and increases imaging speed by more than 2 orders of magnitude without compromising spatial resolution or velocity sensitivity. The minimum flow velocity that can be detected with an axial-line scanning speed of 400 Hz and an average phase change over eight sequential scans is as low as 10 mu m/s, while a spatial resolution of 10 mu m is maintained. Using this technique, we present what are to our knowledge the first phase-resolved OCT/ODT images of blood flow in human shin. (C) 2000 Optical Society of America OCIS codes: 110.4500, 170.3880, 100.5070.

引用

页码：114 / 116

页数：3

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