Electrostatically Mediated Liposome Fusion and Lipid Exchange with a Nanoparticle-Supported Bilayer for Control of Surface Charge, Drug Containment, and Delivery

被引：239

作者：

Liu, Juewen ^{[1
]}

Jiang, Xingmao ^{[1
]}

Ashley, Carlee ^{[2
]}

Brinker, C. Jeffrey ^{[1
,2
,3
,4
]}

机构：

[1] Univ New Mexico, Ctr Microengineered Mat, Albuquerque, NM 87106 USA

[2] Univ New Mexico, Dept Chem & Nucl Engn, Albuquerque, NM 87106 USA

[3] Univ New Mexico, Dept Mol Genet & Microbiol, Albuquerque, NM 87106 USA

[4] Sandia Natl Labs, Albuquerque, NM 87106 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 22期

基金：

美国国家卫生研究院;

关键词：

MESOPOROUS SILICA NANOPARTICLES; RESPONSIVE CONTROLLED-RELEASE; MEMBRANES; SYSTEM; MOLECULES; NEUROTRANSMITTERS; STABILITY; TRANSPORT; PROTEINS; VESICLES;

D O I：

10.1021/ja902039y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The loading and containment of cargo within nanoparticles and their efficient delivery to cells represent a primary challenge in nanomedicine. We report lipid exchange between free and mesoporous silica nanoparticle-supported lipid bilayers as an effective means of containing cargo, controlling charge, and directing delivery to mammalian cells. The delivery of a membrane-impermeable dye (calcein) and a chemotherapeutic drug (doxorubicin) are demonstrated. Exchanged lipid bilayers minimized premature drug release, and an overall positive charge on the supported lipid bilayer effected enhanced delivery.

引用

页码：7567 / +

页数：5

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