Synthesis and evaluation of novel oxazoline MMP inhibitors

被引：17

作者：

Cook, GR ^{[1
]}

Manivannan, E

Underdahl, T

Lukacova, V

Zhang, YF

Balaz, S

机构：

[1] N Dakota State Univ, Ctr Protease Res, Dept Chem Biochem & Mol Biol, Fargo, ND 58105 USA

[2] N Dakota State Univ, Ctr Protease Res, Dept Pharmaceut Sci, Fargo, ND 58105 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 19期

关键词：

MMP inhibitors; oxazolines; heterocycles; zinc binding;

D O I：

10.1016/j.bmcl.2004.07.023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

MMP inhibitors with novel oxazoline zinc binding groups have been synthesized and evaluated. Selectivity for the inhibition of MMP-9 over MMP-1, MMP-2, and MMP-12 has been achieved in several cases. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4935 / 4939

页数：5

共 38 条

[21] Matrix metalloproteinase inhibitors: A structure-activity study [J].

Levy, DE ;

Lapierre, F ;

Liang, WS ;

Ye, WQ ;

Lange, CW ;

Li, XY ;

Grobelny, D ;

Casabonne, M ;

Tyrrell, D ;

Holme, K ;

Nadzan, A ;

Galardy, RE .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (02) :199-223

[22]

LUKACOVA V, 2004, J BIOL CHEM, P279

[23]

Morphy JR, 1995, CURR MED CHEM, V2, P743

[24]

MULLERSTEFFNER HM, 1992, J BIOL CHEM, V267, P9606

[25]

Nagase H, 1997, BIOL CHEM, V378, P151

[26] Strategies for MMP inhibition in cancer:: Innovations for the post-trial era [J].

Overall, CM ;

López-Otín, C .

NATURE REVIEWS CANCER, 2002, 2 (09) :657-672

[27] X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: Implications for inhibitor selectivity [J].

Pavlovsky, AG ;

Williams, MG ;

Ye, QZ ;

Ortwine, DF ;

Purchase, CF ;

White, AD ;

Dhanaraj, V ;

Roth, BD ;

Johnson, LL ;

Hupe, D ;

Humblet, C ;

Blundell, TL .

PROTEIN SCIENCE, 1999, 8 (07) :1455-1462

[28] Membrane-type metalloproteinases in tumor invasion [J].

Polette, M ;

Birembaut, P .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 1998, 30 (11) :1195-1202

[29] New beginnings for matrix metalloproteinase inhibitors: Identification of high-affinity zinc-binding groups [J].

Puerta, DT ;

Lewis, JA ;

Cohen, SM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (27) :8388-8389

[30]

Sternlicht M.D., 2000, Emerg. Ther. Targets, V4, P609, DOI DOI 10.1517/14728222.4.5.609

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