Amelioration of ferric nitrilotriacetate (Fe-NTA) induced renal oxidative stress and tumor promotion response by coumarin (1,2-benzopyrone) in Wistar rats

被引：18

作者：

Khan, N ^{[1
]}

Sharma, S ^{[1
]}

Sultana, S ^{[1
]}

机构：

[1] Hamdard Univ, Sect Chemoprevent & Nutr Toxicol, Dept Med Elementol & Toxicol, Fac Sci, New Delhi 110062, India

来源：

CANCER LETTERS | 2004年 / 210卷 / 01期

关键词：

coumarin; ferric nitrilotriacetate; tumor promotion response; oxidative stress;

D O I：

10.1016/j.canlet.2004.01.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

In this study, we report the modulatory effect of coumarin (1,2-benzopyrone) on Ferric nitrilotri acetate (Fe-NTA) induced renal oxidative stress and tumor promotion response in rats. Fe-NTA (9 mg Fe/kg body weight, intraperitoneally) enhances renal lipid peroxidation, xanthine oxidase, gamma-glutamyl transpeptidase and hydrogen peroxide (H2O2) generation with reduction in antioxidant enzymes and renal glutathione content. It also enhances blood urea nitrogen, serum creatinine, ornithine decarboxylase (ODC) activity and thymidine [H-3] incorporation into renal DNA. Prophylactic treatment of rats with coumarin (10 and 20 mg/kg body weight) resulted in significant recovery of antioxidant enzymes (P<0.001) and renal glutathione content (P<0.01). There was also significant decrease in gamma-glutamyl transpeptidase, lipid peroxidation, xanthine oxidase, H2O2 generation, blood urea nitrogen, serum creatinine, renal ODC activity and DNA synthesis (P<0.001). Thus, our results show that coumarin is a potent chemopreventive agent and suppresses Fe-NTA induced nephrotoxicity in Wistar rats. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：17 / 26

页数：10

共 39 条

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A REVIEW OF THE ENVIRONMENTAL AND MAMMALIAN TOXICOLOGY OF NITRILOTRIACETIC ACID [J].