The effect of combined thrombolysis with rtPA and tirofiban on ischemic brain lesions

被引：82

作者：

Seitz, RJ

Meisel, S

Moll, M

Wittsack, HJ

Junghans, U

Siebler, M

机构：

[1] Univ Dusseldorf, Dept Neurol, D-4000 Dusseldorf, Germany

[2] Univ Dusseldorf, Inst Diagnost Radiol, D-4000 Dusseldorf, Germany

来源：

NEUROLOGY | 2004年 / 62卷 / 11期

关键词：

D O I：

10.1212/01.WNL.0000129480.17345.4A

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To determine the effect of systemic thrombolysis with low-dose recombinant tissue plasminogen activator (rtPA) and the body-weight adjusted platelet GPIIb/IIIa receptor antagonist tirofiban, the authors performed lesion volumetry on magnetic resonance perfusion and diffusion images recorded before thrombolysis and on T2-weighted magnetic resonance images on day 8. Treatment with rtPA and tirofiban (n = 13) resulted in a 50% lesion reduction (p < 0.03), while lesion reduction was less in rtPA treatment (n = 16) and absent in nontreated patients (n = 18).

引用

页码：2110 / 2112

页数：3

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