Size Effect on Cell Uptake in Well-Suspended, Uniform Mesoporous Silica Nanoparticles

被引：881

作者：

Lu, Fang

Wu, Si-Han

Hung, Yann

Mou, Chung-Yuan ^{[1
]}

机构：

[1] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan

来源：

SMALL | 2009年 / 5卷 / 12期

关键词：

cell uptake; mesoporous materials; nanoparticles; particle size; silica; RECEPTOR-MEDIATED ENDOCYTOSIS; HUMAN DENDRITIC CELLS; PARTICLE-SIZE; MOLECULAR-SIEVES; ANTICANCER DRUGS; SURFACE-CHARGE; CANCER-CELLS; IN-VITRO; DELIVERY; BINDING;

D O I：

10.1002/smll.200900005

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A study was conducted to demonstrate the synthesis of monodisperse mesoporous silica nanoparticle (MSN) suspensions and investigate the effect of nanoparticle size on cell uptake. The MSNs were synthesized by adjusting the pH of the reaction medium, leading to a series of MSNs with uniform size ranging from 30-280 nm. The physical properties of the MSNs were characterized with various methods, such as nitrogen adsorption-desorption, transmission electron microscopy (TEM), and X-ray powder diffraction (XRD). The particle size effect on the cell uptake efficiency with human cervical cancer cells and cellular uptake of MSNs of various sizes were investigated by confocal laser scanning microscopy (CLSM). The uptake efficiencies were determined by inductively coupled plasma mass spectrometry (ICP-MS) analysis of total silicon content.

引用

页码：1408 / 1413

页数：6

共 39 条

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