The role of specific and non-specific interactions in receptor-mediated endocytosis of nanoparticles

被引：215

作者：

Decuzzi, P.

Ferrari, M.

机构：

[1] Univ Magna Graecia, BioNEM, Ctr Bio Nanotechnol & Engn Med, I-88100 Catanzaro, Italy

[2] Politecn Bari, CEMEC, Bari, Italy

[3] Univ Texas, Hlth Sci Ctr, Houston, TX 77031 USA

[4] Univ Texas, MD Anderson Canc Ctr, Houston, TX 77031 USA

来源：

BIOMATERIALS | 2007年 / 28卷 / 18期

关键词：

nanobiotechnology; bioadhesion; particle internalization; surface properties; drug delivery;

D O I：

10.1016/j.biomaterials.2007.02.013

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The role of specific and non-specific interactions in the receptor-mediated endocytosis of nanoparticles is analyzed. The characteristic time tau(w), the threshold R-th and optimal R-opt, radii for particle endocytosis are estimated as a function of the binding energy factor C, bond elasticity factor G, and non-specific attractive/repulsive factor Fat the cell-particle interface. It is shown that the contribution of F is as important as that of C and G. General and ready to use formulas are presented that can be a guide in designing nanoparticles with controlled endocytic performances. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2915 / 2922

页数：8

共 16 条

[1] CELL-ADHESION - COMPETITION BETWEEN NONSPECIFIC REPULSION AND SPECIFIC BONDING [J].