Photo-responsive oligonucleotides carrying azobenzene at the 2′-position of uridine

被引:31
作者
Asanuma, H [1 ]
Yoshida, T [1 ]
Ito, T [1 ]
Komiyama, M [1 ]
机构
[1] Univ Tokyo, Grad Sch Engn, Dept Chem & Biotechnol, Bunkyo Ku, Tokyo 1138656, Japan
关键词
azo compounds; isomerization; phosphoramidites; photochemistry;
D O I
10.1016/S0040-4039(99)01547-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Azobenzene residue has been tethered to the 2'-position of uridine in oligonucleotides. On photo-irradiation, the melting temperatures between the modified oligonucleotides and their complementary DNA were significantly changed by the cis-trans isomerization of the azobenzene. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:7995 / 7998
页数:4
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