The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase

被引：216

作者：

Rosengren, E

Aman, P

Thelin, S

Hansson, C

Ahlfors, S

Bjork, P

Jacobsson, L

Rorsman, H

机构：

[1] UNIV LUND HOSP,CTR BLOOD,S-22185 LUND,SWEDEN

[2] LUND UNIV,DEPT PHARMACOL,S-22362 LUND,SWEDEN

[3] UNIV LUND HOSP,DEPT CLIN GENET,S-22185 LUND,SWEDEN

[4] UNIV LUND HOSP,DEPT DERMATOL,S-22185 LUND,SWEDEN

来源：

FEBS LETTERS | 1997年 / 417卷 / 01期

关键词：

macrophage migration inhibitory factor; phenylpyruvate tautomerase; D-dopachrome tautomerase; cytokine;

D O I：

10.1016/S0014-5793(97)01261-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIP is identified as a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine. (C) 1997 Federation of European Biochemical Societies.

引用

页码：85 / 88

页数：4

共 37 条

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