Constrained amino acids, an approach to the synthesis of 3-substituted prolines

被引：46

作者：

Waid, PP ^{[1
]}

Flynn, GA ^{[1
]}

Huber, EW ^{[1
]}

Sabol, JS ^{[1
]}

机构：

[1] HOECHST MARION ROUSSEL INC,CINCINNATI,OH 45215

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 24期

关键词：

D O I：

10.1016/0040-4039(96)00775-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of diastereomeric substituted proline peptidomimetics as conformationally restricted tyrosine derivatives 1a,b has been accomplished utilizing the intramolecular hydroboration-cycloalkylation of azido-olefins 7a,b as the key step. (C) 1996 Elsevier Science Ltd

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页码：4091 / 4094

页数：4

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