Three-dimensional endomicroscopy of the human colon using optical coherence tomography

被引：102

作者：

Adler, Desmond C. ^{[1
,2
]}

Zhou, Chao ^{[1
,2
]}

Tsai, Tsung-Han ^{[1
,2
]}

Schmitt, Joe ^{[3
]}

Huang, Qin ^{[4
,5
]}

Mashimo, Hiroshi ^{[4
,5
]}

Fujimoto, James G. ^{[1
,2
]}

机构：

[1] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA

[2] MIT, Elect Res Lab, Cambridge, MA 02139 USA

[3] LightLab Imaging Inc, Westford, MA 01886 USA

[4] Vet Affairs Boston Healthcare Syst, Boston, MA 02130 USA

[5] Harvard Univ, Sch Med, Cambridge, MA 02139 USA

来源：

OPTICS EXPRESS | 2009年 / 17卷 / 02期

基金：

美国国家科学基金会; 美国国家卫生研究院; 加拿大自然科学与工程研究理事会;

关键词：

DOMAIN MODE-LOCKING; ULTRAHIGH-RESOLUTION; RADIATION PROCTITIS; BARRETTS-ESOPHAGUS; LASER; MICROSCOPY; DYSPLASIA; MANAGEMENT; EPITHELIUM; CARCINOMA;

D O I：

10.1364/OE.17.000784

中图分类号：

O43 [光学];

学科分类号：

070207 [光学];

摘要：

Three-dimensional (3D) endomicroscopy imaging of the human gastrointestinal tract is demonstrated in vivo using a swept source optical coherence tomography (OCT) system. 3D datasets of normal and pathologic regions of the colon, rectum, and anal verge were obtained from seven volunteers undergoing diagnostic or therapeutic colonoscopy. 3D-OCT enables high resolution endomicroscopy examination through visualization of tissue architectural morphology using virtual cross-sectional images with arbitrary orientations as well as en face projection images. Axial image resolutions of 6 mu m in tissue are obtained over a similar to 180 mm(2) field with an imaging range of 1.6 mm. A Fourier domain mode locked (FDML) laser providing a tuning range of 180 nm at a sweep rate of 62 kHz is used as the system light source. This clinical pilot study demonstrates the potential of 3D-OCT for distinguishing normal from pathologic colorectal tissue, assessing endoscopic therapies and healing progression. (C) 2009 Optical Society of America

引用

页码：784 / 796

页数：13

共 42 条

[1]

Three-dimensional endomicroscopy using optical coherence tomography [J].

Adler, Desmond C. ;

Chen, Yu ;

Huber, Robert ;

Schmitt, Joseph ;

Connolly, James ;

Fujimoto, James G. .

NATURE PHOTONICS, 2007, 1 (12) :709-716

[2]

[Anonymous], 2010, Robbins and Cotran pathologic basis of disease, professional edition e-book

[3]

High-resolution imaging of the human esophagus and stomach in vivo using optical coherence tomography [J].

Bouma, BE ;

Tearney, GJ ;

Compton, CC ;

Nishioka, NS .

GASTROINTESTINAL ENDOSCOPY, 2000, 51 (04) :467-474

[4]

Ultrahigh resolution optical coherence tomography of Barrett's esophagus: preliminary descriptive clinical study correlating images with histology [J].

Chen, Y. ;

Aguirre, A. D. ;

Hsiung, P.-L. ;

Desai, S. ;

Herz, P. R. ;

Pedrosa, M. ;

Huang, Q. ;

Figueiredo, M. ;

Huang, S.-W. ;

Koski, A. ;

Schmitt, J. M. ;

Fujimoto, J. G. ;

Mashimo, H. .

ENDOSCOPY, 2007, 39 (07) :599-605

[5]

Sensitivity advantage of swept source and Fourier domain optical coherence tomography [J].

Choma, MA ;

Sarunic, MV ;

Yang, CH ;

Izatt, JA .

OPTICS EXPRESS, 2003, 11 (18) :2183-2189

[6]

Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography [J].

de Boer, JF ;

Cense, B ;

Park, BH ;

Pierce, MC ;

Tearney, GJ ;

Bouma, BE .

OPTICS LETTERS, 2003, 28 (21) :2067-2069

[7]

Formalin application in the treatment of chronic radiation-induced hemorrhagic proctitis - An effective but not risk-free procedure: A prospective study of 33 patients [J].

de Parades, V ;

Etienney, I ;

Bauer, P ;

Bourguignon, J ;

Meary, N ;

Mory, B ;

Sultan, S ;

Taouk, M ;

Thomas, C ;

Atienza, P .

DISEASES OF THE COLON & RECTUM, 2005, 48 (08) :1535-1541

[8]

RADIATION PROCTITIS AFTER PROSTATE CARCINOMA-THERAPY [J].

DONALDSON, SS .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 271 (11) :819-820

[9]

Thin-layer ablation of human esophageal epithelium using a bipolar radiofrequency balloon device [J].

Dunkin, BJ ;

Martinez, J ;

Bejarano, PA ;

Smith, CD ;

Chang, K ;

Livingstone, AS ;

Melvin, WS .

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 2006, 20 (01) :125-130

[10]

The risk of colorectal cancer in ulcerative colitis: a meta-analysis [J].

Eaden, JA ;

Abrams, KR ;

Mayberry, JF .

GUT, 2001, 48 (04) :526-535

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