Characterisation of effector mechanisms at the host:parasite interface during the immune response to tissue-dwelling intestinal nematode parasites

被引：91

作者：

Patel, Nirav ^{[1
]}

Kreider, Timothy ^{[1
]}

Urban, Joseph F., Jr. ^{[2
]}

Gause, William C. ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Med, Newark, NJ 07103 USA

[2] USDA, Beltsville Human Nutr Res Ctr, Diet Genom & Immunol Lab, Beltsville, MD 20705 USA

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2009年 / 39卷 / 01期

关键词：

Parasite; Inflammation; Immune; Intestinal; Nematode; Th2; HOST PROTECTIVE IMMUNITY; MAST-CELL PROTEASE-1; ALTERNATIVELY ACTIVATED MACROPHAGES; LARVAL STRONGYLOIDES-STERCORALIS; EOSINOPHIL CHEMOTACTIC CYTOKINE; TRICHINELLA-SPIRALIS INFECTION; THYMIC STROMAL LYMPHOPOIETIN; HUMAN MONONUCLEAR-CELLS; REGULATORY T-CELLS; TRICHURIS-MURIS;

D O I：

10.1016/j.ijpara.2008.08.003

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The protective immune response that develops following infection with many tissue-dwelling intestinal nematode parasites is characterised by elevations in IL-4 and IL-13 and increased numbers of CD4+ T cells, granulocytes and macrophages. These cells accumulate at the site of infection and in many cases can mediate resistance to these large multicellular pathogens. Recent studies suggest novel potential mechanisms mediated by these immune cell populations through their differential activation and ability to stimulate production of novel effector molecules. These newly discovered protective mechanisms may provide novel strategies to develop immunotherapies and vaccines against this group of pathogens. in this review, we will examine recent studies elucidating mechanisms of host protection against three widely-used experimental murine models of tissue-dwelling intestinal nematode parasites: Heligmosomoides polygyrus, Trichuris muris and Trichinella spiralis. (C) 2008 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：13 / 21

页数：9

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