Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South Korea

被引：47

作者：

Lee, Kyungwon

Kim, Mi-Na ^{[2
]}

Choi, Tae Yeal ^{[3
]}

Cho, Soung-Eun ^{[4
]}

Lee, Seungok ^{[5
]}

Whang, Dong Hee ^{[6
]}

Yong, Dongeun

Chong, Yunsop ^{[1
]}

Woodford, Neil ^{[7
]}

Livermore, David M. ^{[7
]}

机构：

[1] Yonsei Univ, Dept Lab Med, Coll Med, Seoul 120752, South Korea

[2] Univ Ulsan, Coll Med, Seoul, South Korea

[3] Hanyang Univ, Coll Med, Seoul 133791, South Korea

[4] Ewha Womans Univ, Coll Med, Seoul, South Korea

[5] Seoul Clin Lab, Seoul, South Korea

[6] Inje Univ, Coll Med, Seoul, South Korea

[7] Hlth Protect Agcy, Ctr Infect, London NW9 5EQ, England

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2009年 / 33卷 / 06期

关键词：

OXA carbapenemase; IMP-1; VIM-2; SIM-1; Acinetobacter spp; South Korea; BETA-LACTAMASE; BAUMANNII; PSEUDOMONAS; EXPRESSION; RESISTANCE; ISABA1; GENES; HODGE;

D O I：

10.1016/j.ijantimicag.2008.10.009

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Carbapenem-resistant Acinetobacter spp. are being increasingly reported worldwide, including in South Korea, where we examined 144 representative isolates collected in a nationwide hospital survey in 2005. Metallo-beta-lactamases were detected in only 19.4% of isolates, none of which were Acinetobacter baumannii, whereas 74.3% of isolates (mostly A. baumannii) expressed bla(OXA) carbapenemase genes. Among the latter, 47 had bla(OXA-23)-like genes and 56 had upregulated bla(OXA-51)-like variants, including bla(OXA-66), (-83), (-109) and (-115); bla(OXA-115) was a novel variant, detected in two isolates. bla(OXA-72) (bla(OXA-40)-like) was detected in only a single Acinetobacter baylyi isolate, whilst three Acinetobacter calcoaceticus isolates had both bla(VIM-2)-like and bla(OXA-58) genes. Pulsed-field gel electrophoresis (PFGE) suggested the spread of A. baumannii clones with OXA carbapenemases within and between hospitals. In conclusion, the recent increase in imipenem-resistant Acinetobacter spp. from South Korea is mostly due to OXA-type carbapenemases. (C) 2008 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：520 / 524

页数：5

共 20 条

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