p53 and metabolism

被引：779

作者：

Vousden, Karen H. ^{[1
]}

Ryan, Kevin M. ^{[1
]}

机构：

[1] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

来源：

NATURE REVIEWS CANCER | 2009年 / 9卷 / 10期

关键词：

TUMOR-SUPPRESSOR P53; WILD-TYPE P53; CELL-DEATH; GLUCOSE-METABOLISM; RESPONSE ELEMENTS; ENERGY-METABOLISM; OXIDATIVE STRESS; DOWN-REGULATION; AUTOPHAGY; CANCER;

D O I：

10.1038/nrc2715

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although metabolic alterations have been observed in cancer for almost a century, only recently have the mechanisms underlying these changes been identified and the importance of metabolic transformation realized. p53 has been shown to respond to metabolic changes and to influence metabolic pathways through several mechanisms. The contributions of these activities to tumour suppression are complex and potentially rather surprising: some reflect the function of basal p53 levels that do not require overt activation and others might even promote, rather than inhibit, tumour progression.

引用

页码：691 / 700

页数：10

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