The evolving role of 3D domain swapping in proteins

被引:41
作者
Bennett, MJ [1 ]
Eisenberg, D
机构
[1] Univ Calif Los Angeles, Howard Hughes Med Inst, Dept Chem & Biochem, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Howard Hughes Med Inst, Dept Biol Chem, Los Angeles, CA 90095 USA
关键词
D O I
10.1016/j.str.2004.07.004
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
3D domain swapping is increasingly implicated in amyloidosis but also has potential functional advantages in Soluble proteins. indeed, the structure of an NF-kappaB p50 mutant (Chirgadze et al., 2004) demonstrates that 3D domain swapping can rescue function after a destabilizing mutation. This work has wider implications for the evolution of protein oligomers.
引用
收藏
页码:1339 / 1341
页数:3
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