Folate: a magic bullet or a double edged sword for colorectal cancer prevention?

被引:159
作者
Kim, Y-I [1 ]
机构
[1] Univ Toronto, Toronto, ON M5S 1A8, Canada
关键词
D O I
10.1136/gut.2006.095463
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Low folate status might inhibit colorectal carcinogenesis and high folate status may promote colorectal carcinogenesis, contradicting findings from epidemiological studies showing an inverse relationship between folate status and risk of colorectal cancer.
引用
收藏
页码:1387 / 1389
页数:3
相关论文
共 38 条
[1]   Folic acid supplements and fortification affect the risk for neural tube defects, vascular disease and cancer: Evolving science [J].
Bailey, LB ;
Rampersaud, GC ;
Kauwell, GPA .
JOURNAL OF NUTRITION, 2003, 133 (06) :1961S-1968S
[2]   DELAYED TUMOR ONSET IN TRANSGENIC MICE FED A LOW-FOLATE DIET [J].
BILLS, ND ;
HINRICHS, SH ;
MORGAN, R ;
CLIFFORD, AJ .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1992, 84 (05) :332-337
[3]   Homocysteine lowering and cardiovascular events after acute myocardial infarction [J].
Bonaa, KH ;
Njolstad, I ;
Ueland, PM ;
Schirmer, H ;
Tverdal, A ;
Steigen, T ;
Wang, H ;
Nordrehaug, JE ;
Arnesen, E ;
Rasmussen, K .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (15) :1578-1588
[4]   How safe are folic acid supplements? [J].
Campbell, NRC .
ARCHIVES OF INTERNAL MEDICINE, 1996, 156 (15) :1638-1644
[5]   Folate status: Effects on pathways of colorectal carcinogenesis [J].
Choi, SW ;
Mason, JB .
JOURNAL OF NUTRITION, 2002, 132 (08) :2413S-2418S
[6]  
COLE BF, 2002, P AM ASSOC CANC RES, V46, P4399
[7]  
Cooney CA, 2002, J NUTR, V132, p2393S
[9]   Multivitamin use, folate, and colon cancer in women in the nurses' health study [J].
Giovannucci, E ;
Stampfer, MJ ;
Colditz, GA ;
Hunter, DJ ;
Fuchs, C ;
Rosner, BA ;
Speizer, FE ;
Willett, WC .
ANNALS OF INTERNAL MEDICINE, 1998, 129 (07) :517-+
[10]   Epidemiologic studies of folate and colorectal neoplasia: a review [J].
Giovannucci, E .
JOURNAL OF NUTRITION, 2002, 132 (08) :2350S-2355S