Multiplexed molecular detection using encoded microparficles and nanoparticles

被引：8

作者：

Li, Yougen

Luo, Dan

机构：

[1] Cornell Univ, Dept Biol & Environm Engn, Ithaca, NY 14853 USA

[2] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA

来源：

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2006年 / 6卷 / 04期

关键词：

barcode; encoding; microparticle; molecular detection; molecular engineering; multiplex; nanoparricle; nucleic acid engineering;

D O I：

10.1586/14737159.6.4.567

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Signal-encoded microparticles and nanoparticles have been used to label many reactions simultaneously for target identification in assays, and thus are an indispensable part of multiplex technologies. With the increasing demand for multiplexed molecular detection, encoded particles have evolved from pattern encoding to signal-intensity encoding, and also from signal-molecule encapsulation to signal-molecule tagging. The fabrication and utilization of such nano- and microparticles should advance multiplexed analysis. This short review focuses on how these encoded particles work and briefly touches on their applications in multiplexed molecular detection.

引用

收藏

页码：567 / 574

页数：8

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