Molecular and cellular basis of addiction

被引:1027
作者
Nestler, EJ
Aghajanian, GK
机构
[1] YALE UNIV, SCH MED, DEPT PHARMACOL, NEW HAVEN, CT 06508 USA
[2] CONNECTICUT MENTAL HLTH CTR, NEW HAVEN, CT 06508 USA
关键词
D O I
10.1126/science.278.5335.58
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Drug addiction results from adaptations in specific brain neurons caused by repeated exposure to a drug of abuse. These adaptations combine to produce the complex behaviors that define an addicted slate. Progress is being made in identifying such time-dependent, drug-induced adaptations and relating them to specific behavioral features of addiction. Current research needs to understand the types of adaptations that underlie the particularly long-lived aspects of addiction, such as drug craving and relapse, and to identify specific genes that contribute to individual differences in vulnerability to addiction. Understanding the molecular and cellular basis of addictive states will lead to major changes in how addiction is viewed and ultimately treated.
引用
收藏
页码:58 / 63
页数:6
相关论文
共 126 条
[1]   TOLERANCE OF LOCUS COERULEUS NEURONS TO MORPHINE AND SUPPRESSION OF WITHDRAWAL RESPONSE BY CLONIDINE [J].
AGHAJANIAN, GK .
NATURE, 1978, 276 (5684) :186-188
[2]  
AKAOKA H, 1991, J NEUROSCI, V11, P3830
[3]   QX-314 BLOCKS THE POTASSIUM BUT NOT THE SODIUM-DEPENDENT COMPONENT OF THE OPIATE RESPONSE IN LOCUS-CERULEUS NEURONS [J].
ALREJA, M ;
AGHAJANIAN, GK .
BRAIN RESEARCH, 1994, 639 (02) :320-324
[4]  
ALREJA M, 1993, J NEUROSCI, V13, P3525
[5]  
ARDEN JR, 1995, J NEUROCHEM, V65, P1636
[6]   LONG-TERM OPIATE EXPOSURE LEADS TO REDUCTION OF THE ALPHA-I-1 SUBUNIT OF GTP-BINDING PROTEINS [J].
ATTALI, B ;
VOGEL, Z .
JOURNAL OF NEUROCHEMISTRY, 1989, 53 (05) :1636-1639
[7]  
Berhow MT, 1996, J NEUROSCI, V16, P4707
[8]  
Berhow MT, 1996, J NEUROSCI, V16, P8019
[9]   INFLUENCE OF NEUROTROPHIC FACTORS ON MORPHINE-INDUCED AND COCAINE-INDUCED BIOCHEMICAL-CHANGES IN THE MESOLIMBIC DOPAMINE SYSTEM [J].
BERHOW, MT ;
RUSSELL, DS ;
TERWILLIGER, RZ ;
BEITNERJOHNSON, D ;
SELF, DW ;
LINDSAY, RM ;
NESTLER, EJ .
NEUROSCIENCE, 1995, 68 (04) :969-979
[10]   QUANTITATIVE TRAIT LOCI MAPPING OF 3 LOCI CONTROLLING MORPHINE PREFERENCE USING INBRED MOUSE STRAINS [J].
BERRETTINI, WH ;
FERRARO, TN ;
ALEXANDER, RC ;
BUCHBERG, AM ;
VOGEL, WH .
NATURE GENETICS, 1994, 7 (01) :54-58