Enantio- and diastereoselective, stereospecific Mannich-type reactions in water

被引：145

作者：

Hamada, T ^{[1
]}

Manabe, K ^{[1
]}

Kodayashi, S ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 25期

关键词：

D O I：

10.1021/ja048607t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Catalytic asymmetric Mannich-type reactions in water proceeded in high yields and selectivities using a combination of ZnF2 and a chiral diamine that has the methoxy groups on the aromatic rings. In these reactions, either syn- or anti-Mannich adducts were stereospecifically obtained from (E)- or (Z)-silicon enolate, in contrast with most asymmetric Mannich-type reactions. Copyright © 2004 American Chemical Society.

引用

页码：7768 / 7769

页数：2

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