Gold-layered calcium phosphate plasmonic resonants for localized photothermal treatment of human epithelial cancer

被引：10

作者：

Kang, Jinyoung ^{[2
,3
]}

Yang, Jaemoon ^{[1
,2
]}

Lee, Jaewon ^{[2
]}

Oh, Seung Jae ^{[1
]}

Moon, Seyoung ^{[3
,7
]}

Lee, Hong Jae ^{[4
,5
]}

Lee, Sang Cheon ^{[4
,5
]}

Son, Joo-Hiuk ^{[6
]}

Kim, Donghyun ^{[7
]}

Lee, Kwangyeol ^{[8
]}

Suh, Jin-Suck ^{[1
]}

Huh, Yong-Min ^{[1
]}

Haam, Seungjoo ^{[2
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Radiol, Seoul 120752, South Korea

[2] Yonsei Univ, Dept Chem & Biomol Engn, Seoul 120749, South Korea

[3] Yonsei Univ, Program Nanomed Sci & Technol, Seoul 120749, South Korea

[4] Kyung Hee Univ, Dept Oral Biol, Seoul 130701, South Korea

[5] Kyung Hee Univ, Sch Dent, Inst Oral Biol, Seoul 130701, South Korea

[6] Univ Seoul, Dept Phys, Seoul 130743, South Korea

[7] Yonsei Univ, Dept Elect & Elect Engn, Seoul 120749, South Korea

[8] Korea Univ, Dept Chem, Seoul 136701, South Korea

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2009年 / 19卷 / 19期

基金：

新加坡国家研究基金会;

关键词：

THERAPY; NANOSHELLS; NANORODS; NANOCOMPOSITES; NANOCAGES; CELLS;

D O I：

10.1039/b822835c

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We fabricated de novo biocompatible mineral plasmon resonants for localized and systemic treatment of cancer. Biodegradable calcium-phosphate gold nanocomposites were synthesized for inducing a superior surface plasmon resonance effect. The combination of therapeutic antibody, Erbitux (R) and NIR laser with nanocomposites demonstrated the potential for selective bimodal cancer treatment by combination of EGFR-induced signaling inhibition as a systemic treatment and localized photothermal effects caused by the NIR laser.

引用

页码：2902 / 2905

页数：4

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