Biological inorganic and bioinorganic chemistry of neurodegeneration based on prion and Alzheimer diseases

被引:328
作者
Brown, DR [1 ]
Kozlowski, H
机构
[1] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England
[2] Univ Wroclaw, Fac Chem, PL-50383 Wroclaw, Poland
关键词
D O I
10.1039/b401985g
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
A change of the prion protein conformation results in a class of neurodegenerative diseases called the transmissible spongiform encephalopathies ( like mad cow and Creutzfeld-Jakob diseases). The function of the normal prion protein is unknown, although much of recent research demonstrates the it may be a copper binding protein selective for Cu(II). Amyloid precursor protein (APP) releases the 39-42 amino acid peptide, a major constituent of the deposit in plaques of Alzheimer disease brain. Also APP is a metal binding protein, including copper ions. The link between copper and both proteins may provide insight into the role of metals in neurodegenerative pathologies.
引用
收藏
页码:1907 / 1917
页数:11
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