It all sticks together - the APP-related family of proteins and Alzheimer's disease

被引：82

作者：

Bayer, TA

Cappai, R

Masters, CL

Beyreuther, K

Multhaup, G

机构：

[1] Univ Bonn, Med Ctr, Dept Psychiat, D-53105 Bonn, Germany

[2] Univ Melbourne, Dept Pathol, Parkville, Vic 3052, Australia

[3] ZMBH, D-69120 Heidelberg, Germany

来源：

MOLECULAR PSYCHIATRY | 1999年 / 4卷 / 06期

关键词：

APP; APLP1; APLP2;

D O I：

10.1038/sj.mp.4000552

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

in the present review, we shall discuss the pros and cons of a possible functional relationship and contribution of the APP family members (APP, APLP1 and APLP2) to the development of Alzheimer's disease: (I) APP, APLP1 and APLP2 are highly homologous proteins with similar protein domain organization. (2) All APP family proteins have been found to be aggregated in typical Alzheimer's disease lesions. (3) Several other proteins have been Implied to provide a functional link among the APP-related proteins. In normal adult brain APP, APLP1 and APLP2 are involved in synaptic processes important for memory function. We hypothesize that the functional loss of members of the APP family contributes to the gradual cognitive decline in Alzheimer's disease patients.

引用

页码：524 / 528

页数：5

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