Activity of the retinoblastoma family proteins, pRB, p107, and p130, during cellular proliferation and differentiation

被引:112
作者
Sidle, A
Palaty, C
Dirks, P
Wiggan, O
Kiess, M
Gill, RM
Wong, AK
Hamel, PA
机构
[1] UNIV TORONTO, DEPT CELLULAR & MOLEC PATHOL, TORONTO, ON M5S 1A8, CANADA
[2] HOSP SICK CHILDREN, TORONTO, ON M5G 1X8, CANADA
基金
英国医学研究理事会;
关键词
cell cycle; E2F; transcription tumor suppressor; TRANSCRIPTION FACTOR E2F; LARGE T-ANTIGEN; SUSCEPTIBILITY GENE-PRODUCT; SV40; LARGE-T; ABL TYROSINE KINASE; VIRUS-40; HUMAN CYCLIN-A; ADENOVIRUS E1A; COMPLEX-FORMATION; S-PHASE;
D O I
10.3109/10409239609106585
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Genetic evidence from retinoblastoma patients and experiments describing the mechanism of cellular transformation by the DNA tumor viruses have defined a central role for the retinoblastoma protein (pRB) family of tumor suppressors in the normal regulation of the eukaryotic cell cycle. These proteins, pRB, p107, and p130, act in a cell cycle-dependent manner to regulate the activity of a number of important cellular transcription factors, such as the E2F-family, which in turn regulate expression of genes whose products are important for cell cycle progression. In addition, inhibition of E2F activity by the pRB family proteins is required for cell cycle exit after terminal differentiation or nutrient depletion. The loss of functional pRB, due to mutation of both RB1 alleles, results in deregulated E2F activity and a predisposition to specific malignancies. Similarly, inactivation of the pRB family by the transforming proteins of the DNA tumor viruses overcomes cellular quiescence and prevents terminal differentiation by blocking the interaction of pRB, p107, and p130 with the E2F proteins, leading to cell cycle progression and, ultimately, cellular transformation. Together these two lines of evidence implicate the pRB family of negative cell cycle regulators and the E2F family of transcription factors as central components in the cell cycle machinery.
引用
收藏
页码:237 / 271
页数:35
相关论文
共 197 条
  • [61] A CDNA-ENCODING A PRB-BINDING PROTEIN WITH PROPERTIES OF THE TRANSCRIPTION FACTOR E2F
    HELIN, K
    LEES, JA
    VIDAL, M
    DYSON, N
    HARLOW, E
    FATTAEY, A
    [J]. CELL, 1992, 70 (02) : 337 - 350
  • [62] INHIBITION OF E2F-1 TRANSACTIVATION BY DIRECT BINDING OF THE RETINOBLASTOMA PROTEIN
    HELIN, K
    HARLOW, E
    FATTAEY, A
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (10) : 6501 - 6508
  • [63] ROLE OF E2F TRANSCRIPTION FACTOR IN E1A-MEDIATED TRANSACTIVATION OF CELLULAR GENES
    HIEBERT, SW
    BLAKE, M
    AZIZKHAN, J
    NEVINS, JR
    [J]. JOURNAL OF VIROLOGY, 1991, 65 (07) : 3547 - 3552
  • [64] THE INTERACTION OF RB WITH E2F COINCIDES WITH AN INHIBITION OF THE TRANSCRIPTIONAL ACTIVITY OF E2F
    HIEBERT, SW
    CHELLAPPAN, SP
    HOROWITZ, JM
    NEVINS, JR
    [J]. GENES & DEVELOPMENT, 1992, 6 (02) : 177 - 185
  • [65] HIJMANS EM, 1995, MOL CELL BIOL, V15, P3082
  • [66] REGULATION OF RETINOBLASTOMA PROTEIN FUNCTIONS BY ECTOPIC EXPRESSION OF HUMAN CYCLINS
    HINDS, PW
    MITTNACHT, S
    DULIC, V
    ARNOLD, A
    REED, SI
    WEINBERG, RA
    [J]. CELL, 1992, 70 (06) : 993 - 1006
  • [67] THE REGIONS OF THE RETINOBLASTOMA PROTEIN NEEDED FOR BINDING TO ADENOVIRUS-E1A OR ADENOVIRUS-SV40 LARGE T-ANTIGEN ARE COMMON SITES FOR MUTATIONS
    HU, QJ
    DYSON, N
    HARLOW, E
    [J]. EMBO JOURNAL, 1990, 9 (04) : 1147 - 1155
  • [68] SUPPRESSION OF THE NEOPLASTIC PHENOTYPE BY REPLACEMENT OF THE RB GENE IN HUMAN CANCER-CELLS
    HUANG, HJS
    YEE, JK
    SHEW, JY
    CHEN, PL
    BOOKSTEIN, R
    FRIEDMANN, T
    LEE, EYHP
    LEE, WH
    [J]. SCIENCE, 1988, 242 (4885) : 1563 - 1566
  • [69] EDITORIAL OVERVIEW - ONCOGENES AND THE CELL-CYCLE
    HUNTER, T
    [J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 1993, 3 (01) : 1 - 4
  • [70] CYCLINS AND CANCER .2. CYCLIN-D AND CDK INHIBITORS COME OF AGE
    HUNTER, T
    PINES, J
    [J]. CELL, 1994, 79 (04) : 573 - 582