Sixty isolates of Enterobacteriaceae resistant to beta-lactam antibiotics were collected over a period of 2 years in Switzerland and screened by hybridization for the carriage of SHV genes. Thirty-four positive strains were found, and their SHV genes were amplified and sequenced. SHV extended-spectrum beta-lactamases (ESBLs) were found: 13 strains contained SHV-2a, 12 harbored SHV-2, and SHV-5 was found twice. Four strains were shown to contain SHV-1. In addition, we report two new SHV variants, termed SHV-11 (non-ESBL) and SHV-12 (ESBL). In spite of the carriage of SHV ESBLs, many strains showed only low resistance to one or more third-generation cephalosporins. In addition, 26 did not transfer the bla(SHV) gene in mating experiments.
机构:
UNIV LAVAL, FAC MED, DEPT MICROBIOL, GEN GENET LAB, QUEBEC CITY G1K 7P4, QUEBEC, CANADAUNIV LAVAL, FAC MED, DEPT MICROBIOL, GEN GENET LAB, QUEBEC CITY G1K 7P4, QUEBEC, CANADA
MERCIER, J
LEVESQUE, RC
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机构:
UNIV LAVAL, FAC MED, DEPT MICROBIOL, GEN GENET LAB, QUEBEC CITY G1K 7P4, QUEBEC, CANADAUNIV LAVAL, FAC MED, DEPT MICROBIOL, GEN GENET LAB, QUEBEC CITY G1K 7P4, QUEBEC, CANADA
机构:
UNIV LAVAL, FAC MED, DEPT MICROBIOL, GEN GENET LAB, QUEBEC CITY G1K 7P4, QUEBEC, CANADAUNIV LAVAL, FAC MED, DEPT MICROBIOL, GEN GENET LAB, QUEBEC CITY G1K 7P4, QUEBEC, CANADA
MERCIER, J
LEVESQUE, RC
论文数: 0引用数: 0
h-index: 0
机构:
UNIV LAVAL, FAC MED, DEPT MICROBIOL, GEN GENET LAB, QUEBEC CITY G1K 7P4, QUEBEC, CANADAUNIV LAVAL, FAC MED, DEPT MICROBIOL, GEN GENET LAB, QUEBEC CITY G1K 7P4, QUEBEC, CANADA