Survey and molecular genetics of SHV beta-lactamases in Enterobacteriaceae in Switzerland: Two novel enzymes, SHV-11 and SHV-12

被引:134
作者
NueschInderbinen, MT [1 ]
Kayser, FH [1 ]
Hachler, H [1 ]
机构
[1] UNIV ZURICH,DEPT MED MICROBIOL,CH-8028 ZURICH,SWITZERLAND
关键词
D O I
10.1128/AAC.41.5.943
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Sixty isolates of Enterobacteriaceae resistant to beta-lactam antibiotics were collected over a period of 2 years in Switzerland and screened by hybridization for the carriage of SHV genes. Thirty-four positive strains were found, and their SHV genes were amplified and sequenced. SHV extended-spectrum beta-lactamases (ESBLs) were found: 13 strains contained SHV-2a, 12 harbored SHV-2, and SHV-5 was found twice. Four strains were shown to contain SHV-1. In addition, we report two new SHV variants, termed SHV-11 (non-ESBL) and SHV-12 (ESBL). In spite of the carriage of SHV ESBLs, many strains showed only low resistance to one or more third-generation cephalosporins. In addition, 26 did not transfer the bla(SHV) gene in mating experiments.
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页码:943 / 949
页数:7
相关论文
共 59 条
  • [31] BETA-LACTAMASES IN LABORATORY AND CLINICAL RESISTANCE
    LIVERMORE, DM
    [J]. CLINICAL MICROBIOLOGY REVIEWS, 1995, 8 (04) : 557 - &
  • [32] Detection of SHV-5 extended-spectrum beta-lactamase in Klebsiella pneumoniae strains isolated in Italy
    Marchese, A
    Arlet, G
    Schito, GC
    Lagrange, PH
    Philippon, A
    [J]. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1996, 15 (03) : 245 - 248
  • [33] In vivo selection of porin-deficient mutants of Klebsiella pneumoniae with increased resistance to cefoxitin and expanded-spectrum cephalosporins
    MartinezMartinez, L
    HernandezAlles, S
    Alberti, S
    Tomas, JM
    Benedi, VJ
    Jacoby, GA
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (02) : 342 - 348
  • [34] CLONING OF SHV-2, OHIO-1, AND OXA-6 BETA-LACTAMASES AND CLONING AND SEQUENCING OF SHV-1 BETA-LACTAMASE
    MERCIER, J
    LEVESQUE, RC
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (08) : 1577 - 1583
  • [35] NEW EXTENDED-SPECTRUM TEM-TYPE BETA-LACTAMASE FROM SALMONELLA-ENTERICA SUBSP ENTERICA ISOLATED IN A NOSOCOMIAL OUTBREAK
    MOROSINI, MI
    CANTON, R
    MARTINEZBELTRAN, J
    NEGRI, MC
    PEREZDIAZ, JC
    BAQUERO, F
    BLAZQUEZ, J
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (02) : 458 - 461
  • [36] CHARACTERIZATION OF AN SHV-5 RELATED EXTENDED BROAD-SPECTRUM BETA-LACTAMASE IN ENTEROBACTERIACEAE FROM WESTERN-AUSTRALIA
    MULGRAVE, L
    ATTWOOD, PV
    [J]. PATHOLOGY, 1993, 25 (01) : 71 - 75
  • [37] *NAT COMM CLIN LAB, 1993, PERF STAND ANT DISK
  • [38] National Committee for Clinical Laboratory Standards, 1993, METH DIL ANT SUSC TE
  • [39] MOLECULAR CHARACTERIZATION OF THE GENE ENCODING SHV-3 BETA-LACTAMASE RESPONSIBLE FOR TRANSFERABLE CEFOTAXIME RESISTANCE IN CLINICAL ISOLATES OF KLEBSIELLA-PNEUMONIAE
    NICOLAS, MH
    JARLIER, V
    HONORE, N
    PHILIPPON, A
    COLE, ST
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (12) : 2096 - 2100
  • [40] NEW SYSTEM BASED ON SITE-DIRECTED MUTAGENESIS FOR HIGHLY ACCURATE COMPARISON OF RESISTANCE LEVELS CONFERRED BY SHV BETA-LACTAMASES
    NUESCHINDERBINEN, MT
    HACHLER, H
    KAYSER, FH
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (08) : 1726 - 1730