Polycystins: From mechanosensation to gene regulation

被引：119

作者：

Delmas, P ^{[1
]}

机构：

[1] CNRS, UMR 6150, Lab Neurophysiol Cellulaire, Fac Med,IFR Jean Roche, F-13916 Marseille 20, France

来源：

CELL | 2004年 / 118卷 / 02期

关键词：

D O I：

10.1016/j.cell.2004.07.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polycystin proteins have been suggested to form mechanosensory transduction complexes involved in a variety of biological functions including sperm fertilization, mating behavior, and asymmetric gene expression in different species. Furthermore, their dys-function is the cause of cyst formation in human kidney disease. This review focuses on the pros and cons of their candidacy as mechanically gated channels and on recent findings that have significantly advanced our physiological insight.

引用

页码：145 / 148

页数：4

共 19 条

[1] Hypotonicity induces TRPV4-mediated nociception in rat [J].

Alessandri-Haber, N ;

Yeh, JJ ;

Boyd, AE ;

Parada, CA ;

Chen, XJ ;

Reichling, DB ;

Levine, JD .

NEURON, 2003, 39 (03) :497-511

[2] A polycystic kidney-disease gene homologue required for male mating behaviour in C-elegans [J].

Barr, MM ;

Sternberg, PW .

NATURE, 1999, 401 (6751) :386-389

[3] PKD1 induces p21waf1 and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2 [J].

Bhunia, AK ;

Piontek, K ;

Boletta, A ;

Liu, LJ ;

Qian, F ;

Xu, PN ;

Germino, FJ ;

Germino, GG .

CELL, 2002, 109 (02) :157-168

[4] Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2 [J].

Delmas, P ;

Nomura, H ;

Li, XG ;

Lakkis, M ;

Luo, Y ;

Segal, Y ;

Fernández-Fernández, JM ;

Harris, P ;

Frischauf, AM ;

Brown, DA ;

Zhou, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (13) :11276-11283

[5] Gating of the polycystin ion channel signaling complex in neurons and kidney cells [J].

Delmas, P ;

Nauli, SM ;

Li, XG ;

Coste, B ;

Osorio, N ;

Crest, M ;

Brown, DA ;

Zhou, J .

FASEB JOURNAL, 2004, 18 (02) :740-+

[6] The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton [J].

Gallagher, AR ;

Cedzich, A ;

Gretz, N ;

Somlo, S ;

Witzgall, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (08) :4017-4022

[7] The polycystic kidney disease 1 gene product modulates Wnt signaling [J].

Kim, E ;

Arnould, T ;

Sellin, LK ;

Benzing, T ;

Fan, MJ ;

Grüning, W ;

Sokol, SY ;

Drummond, I ;

Walz, G .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (08) :4947-4953

[8] Polycystin-2 is an intracellular calcium release channel [J].

Koulen, P ;

Cai, YQ ;

Geng, L ;

Maeda, Y ;

Nishimura, S ;

Witzgall, R ;

Ehrlich, BE ;

Somlo, S .

NATURE CELL BIOLOGY, 2002, 4 (03) :191-197

[9] Polycystin-2 associates with tropomyosin-1, an actin microfilament component [J].

Li, Q ;

Dai, Y ;

Guo, L ;

Liu, Y ;

Hao, CH ;

Wu, GQ ;

Basora, N ;

Michalak, M ;

Chen, XZ .

JOURNAL OF MOLECULAR BIOLOGY, 2003, 325 (05) :949-962

[10] Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor [J].

Liedtke, W ;

Choe, Y ;

Martí-Renom, MA ;

Bell, AM ;

Denis, CS ;

Sali, A ;

Hudspeth, AJ ;

Friedman, JM ;

Heller, S .

CELL, 2000, 103 (03) :525-535

← 1 2 →