Polycystins: From mechanosensation to gene regulation

被引：119

作者：

Delmas, P ^{[1
]}

机构：

[1] CNRS, UMR 6150, Lab Neurophysiol Cellulaire, Fac Med,IFR Jean Roche, F-13916 Marseille 20, France

来源：

CELL | 2004年 / 118卷 / 02期

关键词：

D O I：

10.1016/j.cell.2004.07.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polycystin proteins have been suggested to form mechanosensory transduction complexes involved in a variety of biological functions including sperm fertilization, mating behavior, and asymmetric gene expression in different species. Furthermore, their dys-function is the cause of cyst formation in human kidney disease. This review focuses on the pros and cons of their candidacy as mechanically gated channels and on recent findings that have significantly advanced our physiological insight.

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收藏

页码：145 / 148

页数：4

相关论文

共 19 条

[11] Two populations of node monocilia initiate left-right asymmetry in the mouse [J].

McGrath, J ;

Somlo, S ;

Makova, S ;

Tian, X ;

Brueckner, M .

CELL, 2003, 114 (01) :61-73

[12] The sea urchin sperm receptor for egg jelly is a modular protein with extensive homology to the human polycystic kidney disease protein, PKD1 [J].

Moy, GW ;

Mendoza, LM ;

Schulz, JR ;

Swanson, WJ ;

Glabe, CG ;

Vacquier, VD .

JOURNAL OF CELL BIOLOGY, 1996, 133 (04) :809-817

[13] Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells [J].

Nauli, SM ;

Alenghat, FJ ;

Luo, Y ;

Williams, E ;

Vassilev, P ;

Lil, XG ;

Elia, AEH ;

Lu, WN ;

Brown, EM ;

Quinn, SJ ;

Ingber, DE ;

Zhou, J .

NATURE GENETICS, 2003, 33 (02) :129-137

[14] Polycystin-2 associates with the polycystin-1 homolog, suREJ3, and localizes to the acrosomal region of sea urchin spermatozoa [J].

Neill, AT ;

Moy, GW ;

Vacquier, VD .

MOLECULAR REPRODUCTION AND DEVELOPMENT, 2004, 67 (04) :472-477

[15] Polycystin-1 activation of c-jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins [J].

Parnell, SC ;

Magenheimer, BS ;

Maser, RL ;

Zien, CA ;

Frischauf, AM ;

Calvet, JP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (22) :19566-19572

[16] Bending the MDCK cell primary cilium increases intracellular calcium [J].

Praetorius, HA ;

Spring, KR .

JOURNAL OF MEMBRANE BIOLOGY, 2001, 184 (01) :71-79

[17] Autosomal dominant polycystic kidney disease: Molecular genetics and pathophysiology [J].

Sutters, M ;

Germino, GG .

JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 2003, 141 (02) :91-101

[18] A flagellar polycystin-2 homolog required for male fertility in Drosophila [J].

Watnick, TJ ;

Jim, Y ;

Matunis, E ;

Kernan, MJ ;

Montell, C .

CURRENT BIOLOGY, 2003, 13 (24) :2179-2184

[19] Polycystin-1 interacts with intermediate filaments. [J].

Xu, GM ;

Sikaneta, T ;

Sullivan, BM ;

Zhang, QH ;

Andreucci, M ;

Stehle, T ;

Drummond, L ;

Arnaout, MA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (49) :46544-46552