Import and assembly of proteins into mitochondria of mammalian cells

被引：138

作者：

Hoogenraad, NJ

Ward, LA

Ryan, MT

机构：

[1] Department of Biochemistry, La Trobe University, Melbourne

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2002年 / 1592卷 / 01期

基金：

澳大利亚研究理事会;

关键词：

import; TOM; TIM; molecular chaperone; mitochondrion;

D O I：

10.1016/S0167-4889(02)00268-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Most of our knowledge regarding the process of protein import into mitochondria has come from research employing fungal systems. This review outlines recent advances in our understanding of this process in mammalian cells. In particular, we focus on the characterisation of cytosolic molecular chaperones that are involved in binding to mitochondrial-targeted preproteins, as well as the identification of both conserved and novel subunits of the import machineries of the outer and inner mitochondrial membranes. We also discuss diseases associated with defects in import and assembly of mitochondrial proteins and what is currently known about the regulation of import in mammals. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：97 / 105

页数：9

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