Cell biology - Moving in mysterious ways

被引：16

作者：

Condliffe, AM

Hawkins, PT

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, Dept Med, Cambridge CB2 2QQ, England

[2] Univ Cambridge, Papworth Hosp, Sch Clin Med, Dept Med, Cambridge CB2 2QQ, England

[3] Babraham Inst, Cambridge CB2 4AT, England

来源：

NATURE | 2000年 / 404卷 / 6774期

关键词：

D O I：

10.1038/35004693

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Certain white blood cells home in on pathogens attacking the body by following gradients of chemoattractant to their targets. Cell movement in this chemotactic process requires extension of the cell's leading edge. That, it now emerges, stems from generation of lipid signals by an enzyme called phosphoinositide-3-OH kinase. The result is a highly polarized signalling cascade which leads to directed movement.

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页码：135 / +

页数：2

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