Synthesis of C-2 symmetric potential inhibitors of HIV-1 protease from D-mannitol

被引：4

作者：

Niklasson, G

Kvarnstrom, I

Classon, B

Samuelsson, B

Nillroth, U

Danielson, H

Karlen, A

Hallberg, A

机构：

[1] UNIV STOCKHOLM,ARRHENIUS LAB,DEPT ORGAN CHEM,S-10691 STOCKHOLM,SWEDEN

[2] LINKOPING UNIV,DEPT CHEM,S-58183 LINKOPING,SWEDEN

[3] UNIV UPPSALA,CTR BIOMED,DEPT BIOCHEM,S-75123 UPPSALA,SWEDEN

[4] UNIV UPPSALA,CTR BIOMED,DEPT ORGAN PHARMACEUT CHEM,S-75123 UPPSALA,SWEDEN

[5] ASTRA HASSLE AB,S-43183 MOLNDAL,SWEDEN

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 1996年 / 15卷 / 05期

关键词：

D O I：

10.1080/07328309608005674

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

D-Mannitol was used as precursor for the synthesis of acyclic C-2 symmetric potential HIV-1 protease inhibitors. The 1- and 6-hydroxy groups of D-mannitol were substituted by -NHBoc, -NHValZ, -SAr, -SOAr and -SO2Ar and the 2- and 5-hydroxy groups were benzylated. In some products one of the central hydroxyl groups was either inverted or deoxygenated. Despite a close structural similarity to previously published inhibitors none of the products showed significant inhibitory activity against HIV-1 protease.

引用

页码：555 / 569

页数：15

共 23 条

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