SYNTHESIS OF C2-SYMMETRICAL HIV-1 PROTEASE INHIBITORS FROM D-MANNITOL

被引:33
作者
JADHAV, PK
WOERNER, FJ
机构
[1] Research and Development Division, Discovery Chemistry The DuPont Merck Pharmaceutical Company, Wilmington, DE 19880-0328, Experimental Stations
关键词
D O I
10.1016/S0960-894X(01)80218-3
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Synthesis of C2-symmetric HIV-1 protease inhibitors from D-mannitol is described.
引用
收藏
页码:353 / 356
页数:4
相关论文
共 27 条
[1]  
ABUDT KH, 1991, Patent No. 4030350
[2]   AN INHIBITOR OF THE PROTEASE BLOCKS MATURATION OF HUMAN AND SIMIAN IMMUNODEFICIENCY VIRUSES AND SPREAD OF INFECTION [J].
ASHORN, P ;
MCQUADE, TJ ;
THAISRIVONGS, S ;
TOMASSELLI, AG ;
TARPLEY, WG ;
MOSS, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (19) :7472-7476
[3]   ISOLATION OF A T-LYMPHOTROPIC RETROVIRUS FROM A PATIENT AT RISK FOR ACQUIRED IMMUNE-DEFICIENCY SYNDROME (AIDS) [J].
BARRESINOUSSI, F ;
CHERMANN, JC ;
REY, F ;
NUGEYRE, MT ;
CHAMARET, S ;
GRUEST, J ;
DAUGUET, C ;
AXLERBLIN, C ;
VEZINETBRUN, F ;
ROUZIOUX, C ;
ROZENBAUM, W ;
MONTAGNIER, L .
SCIENCE, 1983, 220 (4599) :868-871
[4]   MAPPING ACTIVE SITE OF PAPAIN WITH AID OF PEPTIDE SUBSTRATES AND INHIBITORS [J].
BERGER, A ;
SCHECHTER, I .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1970, 257 (813) :249-+
[5]   X-RAY CRYSTAL-STRUCTURE OF THE HIV PROTEASE COMPLEX WITH L-700,417, AN INHIBITOR WITH PSEUDO C2 SYMMETRY [J].
BONE, R ;
VACCA, JP ;
ANDERSON, PS ;
HOLLOWAY, MK .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (24) :9382-9384
[6]  
CHENARA B, 1991, BIOMED CHEM LETT, V1, P333
[7]  
DARKE PL, 1989, J BIOL CHEM, V264, P2307
[8]  
DRYER GB, 1989, P NATL ACAD SCI USA, V86, P9752
[9]   NUCLEOPHILIC OPENING OF CHIRAL BIS(AZIRIDINES) - A ROUTE TO ENANTIOMERICALLY PURE ALPHA-AMINO ALDEHYDES OR ACIDS AND POLYSUBSTITUTED PIPERIDINES [J].
DUREAULT, A ;
TRANCHEPAIN, I ;
DEPEZAY, JC .
JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (22) :5324-5330
[10]   DESIGN, ACTIVITY, AND 2.8 A CRYSTAL-STRUCTURE OF A C2 SYMMETRICAL INHIBITOR COMPLEXED TO HIV-1 PROTEASE [J].
ERICKSON, J ;
NEIDHART, DJ ;
VANDRIE, J ;
KEMPF, DJ ;
WANG, XC ;
NORBECK, DW ;
PLATTNER, JJ ;
RITTENHOUSE, JW ;
TURON, M ;
WIDEBURG, N ;
KOHLBRENNER, WE ;
SIMMER, R ;
HELFRICH, R ;
PAUL, DA ;
KNIGGE, M .
SCIENCE, 1990, 249 (4968) :527-533