The second wave of synthetic biology: from modules to systems

被引：780

作者：

Purnick, Priscilla E. M. ^{[1
]}

Weiss, Ron ^{[1
]}

机构：

[1] Princeton Univ, Dept Elect Engn, Princeton, NJ 08544 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2009年 / 10卷 / 06期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

CELL-CELL COMMUNICATION; STOCHASTIC GENE-EXPRESSION; COMPUTER-AIDED-DESIGN; COMPUTATIONAL DESIGN; SIGNALING ELEMENTS; NOISE-PROPAGATION; POSITIVE-FEEDBACK; ESCHERICHIA-COLI; MAMMALIAN-CELLS; TOGGLE SWITCH;

D O I：

10.1038/nrm2698

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Synthetic biology is a research field that combines the investigative nature of biology with the constructive nature of engineering. Efforts in synthetic biology have largely focused on the creation and perfection of genetic devices and small modules that are constructed from these devices. But to view cells as true 'programmable' entities, it is now essential to develop effective strategies for assembling devices and modules into intricate, customizable larger scale systems. The ability to create such systems will result in innovative approaches to a wide range of applications, such as bioremediation, sustainable energy production and biomedical therapies.

引用

页码：410 / 422

页数：13

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