Synthetic potential of cloned fucosyl-transferase III and VI

被引：24

作者：

Baisch, G ^{[1
]}

Ohrlein, R ^{[1
]}

Katopodis, A ^{[1
]}

Streiff, M ^{[1
]}

Kolbinger, F ^{[1
]}

机构：

[1] NOVARTIS PHARMA AG,CH-4002 BASEL,SWITZERLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(97)00429-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two cloned fucosyl-transferases, fuc-t III and fuc-t VI, are probed with non-natural donor-sugars, in which the natural fucose moiety is replaced by mono-saccharides modified in their 2- or 6-positions, Despite their close sequence homology, the investigated transferases exhibit significant differences in their substrate recognition. (C) 1997 Elsevier Science Ltd.

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页码：2447 / 2450

页数：4

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