Immense promises for tiny molecules - Uncovering miRNA functions

被引：28

作者：

le Sage, Carlos ^{[1
]}

Agami, Reuven ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Tumor Biol, Amsterdam, Netherlands

来源：

CELL CYCLE | 2006年 / 5卷 / 13期

关键词：

microRNA; functional genetics; tumorigenesis; cancer; screens;

D O I：

10.4161/cc.5.13.2890

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

With the human genome fully sequenced, the need to obtain functional knowledge of many genes became apparent. Amongst them is a large set of recently discovered genes with powerful promise: the microRNA family. Accumulating data assigned functions in a wide array of biological processes to some miRNAs. Here we review the main approaches used to identify and validate miRNAs and describe ways to discover their functions. As potential effectors of many cellular pathways, mis-expression of miRNAs has been implicated in human cancer.

引用

页码：1415 / 1421

页数：7

共 67 条

[1] Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation [J].

Bagga, S ;

Bracht, J ;

Hunter, S ;

Massirer, K ;

Holtz, J ;

Eachus, R ;

Pasquinelli, AE .

CELL, 2005, 122 (04) :553-563

[2] Prediction and validation of microRNAs and their targets [J].

Bentwich, I .

FEBS LETTERS, 2005, 579 (26) :5904-5910

[3] Identification of hundreds of conserved and nonconserved human microRNAs [J].

Bentwich, I ;

Avniel, A ;

Karov, Y ;

Aharonov, R ;

Gilad, S ;

Barad, O ;

Barzilai, A ;

Einat, P ;

Einav, U ;

Meiri, E ;

Sharon, E ;

Spector, Y ;

Bentwich, Z .

NATURE GENETICS, 2005, 37 (07) :766-770

[4] Phylogenetic shadowing and computational identification of human microRNA genes [J].

Berezikov, E ;

Guryev, V ;

van de Belt, J ;

Wienholds, E ;

Plasterk, RHA ;

Cuppen, E .

CELL, 2005, 120 (01) :21-24

[5] Principles of MicroRNA-target recognition [J].

Brennecke, J ;

Stark, A ;

Russell, RB ;

Cohen, SM .

PLOS BIOLOGY, 2005, 3 (03) :404-418

[6] bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila [J].

Brennecke, J ;

Hipfner, DR ;

Stark, A ;

Russell, RB ;

Cohen, SM .

CELL, 2003, 113 (01) :25-36

[7] Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs [J].

Cai, XZ ;

Hagedorn, CH ;

Cullen, BR .

RNA, 2004, 10 (12) :1957-1966

[8] Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers [J].

Calin, GA ;

Sevignani, C ;

Dan Dumitru, C ;

Hyslop, T ;

Noch, E ;

Yendamuri, S ;

Shimizu, M ;

Rattan, S ;

Bullrich, F ;

Negrini, M ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (09) :2999-3004

[9] MUTATIONS THAT LEAD TO REITERATIONS IN THE CELL LINEAGES OF C-ELEGANS [J].

CHALFIE, M ;

HORVITZ, HR ;

SULSTON, JE .

CELL, 1981, 24 (01) :59-69

[10] MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells [J].

Chan, JA ;

Krichevsky, AM ;

Kosik, KS .

CANCER RESEARCH, 2005, 65 (14) :6029-6033

← 1 2 3 4 5 6 7 →