Prediction and validation of microRNAs and their targets

被引：290

作者：

Bentwich, I ^{[1
]}

机构：

[1] Rosetta Genom Ltd, IL-76706 Rehovot, Israel

来源：

FEBS LETTERS | 2005年 / 579卷 / 26期

关键词：

microRNA; target; prediction; algorithms; validation;

D O I：

10.1016/j.febslet.2005.09.040

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs are short non-coding RNAs that inhibit translation of target genes by binding to their mRNAs, and have been shown to play a central role in gene regulation in health and disease. Sophisticated computer-based prediction approaches of microRNAs and of their targets, and effective biological validation techniques for validating these predictions, now play a central role in discovery of microRNAs and elucidating their functions. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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页码：5904 / 5910

页数：7

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