The first Bischler-Napieralski cyclization in a room temperature ionic liquid

被引：63

作者：

Judeh, ZMA

Ching, CB

Bu, J

McCluskey, A

机构：

[1] Natl Univ Singapore, Chem & Proc Engn Ctr, Singapore 117576, Singapore

[2] Univ Newcastle, Sch Environm & Life Sci, Callaghan, NSW 2308, Australia

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 29期

关键词：

ionic liquids; isoquinolines; Bischler-Napieralski cyclization;

D O I：

10.1016/S0040-4039(02)00998-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have demonstrated the use of the room temperature ionic liquid, 1-butyl-3-methylimidazoliumhexafluorophosphate ([bmim]PF6), as an environmentally benign solvent for the preparation of isoquinoline derivatives through Bischler-Napieralski cyclization under mild conditions with excellent purity and yields. The role of HE as a catalyst in the reaction was also investigated. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：5089 / 5091

页数：3

共 35 条

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